Simona Mrakic Sposta

Researcher at the Italian National Council of Research and from 2020 at current, University Telematica San Raffaele (UNIROMA 5), course of Human Anatomy (BIO-16), in Corsi di Laurea Scienze Motorie e Scienze Motorie curriculum Calcio (L22); Corso di Laurea Scienze e tecniche delle attività motorie preventive e adattate (LM67).  From 2017 to 2021, contract Professor at University of Milan (UNIMI) course of Human Anatomy and Histology, (BIO-16), at Discipline morfologiche (D7605) - modulo di Anatomia/Istologia; Basi biologiche e morfologiche della vita (D710G) in Corsi di Laurea in Tecniche di Neurofisiopatologia (L/SNT3) e Terapia Occupazionale (L/SNT2).  The research fields include studies on oxidative stress, redox status, inflammation and organ damage in: physiological (i.e: at rest in basal condition; during exercise; acute and chronic hypoxia, hyperoxia), pathological conditions (i.e: neurological, metabolic, muscle disease) and/or during/after dietary supplementation (i.e. oxiprolina, folic acid, R-Thioctic acid, nitrate), or specific diet (i.e. ketogenica). A part of research has focused, especially, on physiological adaptation to whole body in extreme condition/environmental (high altitude, hypobaric and normobaric hypoxia, saturation diving, apnea, space) with or without adaptation to exercise. Furthermore, another part of researcher is focused on muscle atrophy, with consequently sarcopenia and aging process. Focus on measurements of oxidative damage biomarkers by enzymatic-immuno and fluorescent-assays and direct free radicals and antioxidant detection by Electron Paramagnetic Resonance (EPR). Measures of Reactive Oxygen Species (ROS) productions and antioxidant capacity in biological samples (blood, saliva, urine, cell, and tissues: in vivo and in vitro by human and animals) by EPR technique. Analysis of specific biomarkers such as: Dopamine, Serotonin, Glutamates, GFAP, BDNF linkages to disorders/status and/or pathologies. Therefore, she continues to study the effects of non-invasive cortical stimulation (tDCS), rehabilitation, by quantitative EEG signals (power spectrum, coherence analysis) in neurological disorders (i.e.: Multiple Sclerosis, Alzheimer). In the previous year, has studied the effects and physio-pathological mechanisms of: transcranial Direct Current Stimulation (tDCS), in health and disease. Other:  Qualified as Associate Professor N6/01 (31/03/2017); Member ad Secretary of Italian Society of Mountain Medicine, SIMeM.